Reactions of organolithium reagents with quinazoline derivatives
نویسندگان
چکیده
منابع مشابه
Substitution of a bridgehead bromide by primary organolithium reagents.
The reaction of ketone 1 with primary organolithium reagents in THF/HMPA affords not the expected carbonyl addition product but the product of bromide substitution, in reasonable yield.
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Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon-carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or carbon-heteroatom bond formation via the Buchwald-Hartwig cross-coupling to yield novel polysubstituted derivatives. This review presents an overview ...
متن کاملThe effect of HMPA on the reactivity of epoxides, aziridines, and alkyl halides with organolithium reagents.
A kinetic study of the effect of added HMPA cosolvent on the reaction of 2-lithio-1,3-dithiane (1), bis(phenylthio)methyllithium (2), and bis(3,5-bistrifluoromethylphenylthio)methyllithium (3) with methyloxirane (propylene oxide), N-tosyl-2-methylaziridine, and the several alkyl halides (BuCl, BuBr, BuI, allyl chloride) was carried out. Widely varied rate effects of HMPA on these SN2 substituti...
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ژورنال
عنوان ژورنال: Arkivoc
سال: 2012
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.0013.704